Jo, Sung Duk Nam, Gi-Hoon Kwak, Gijung Yang, Yoosoo Kwon, Ick Chan 2024-01-20T00:01:52Z 2024-01-20T00:01:52Z 2021-09-03 2017-12 1748-0132 https://pubs.kist.re.kr/handle/201004/121986 Although cancer immunotherapy, represented by chimeric antigen receptor (CAR) T-cell therapy and immune checkpoint-blockade therapies, has shown durable outcomes, the percentage of patients that respond to these approaches remains modest to date. However, encouraging recent advances suggest that nanotechnology has the potential to enhance the efficacy of such immunotherapies by improving the delivery, biodistribution, and release-kinetics of immunostimulatory small molecules and biologics in targeted tissues. A variety of synthetic nanoparticles, including polymeric nanoparticles, liposomes and inorganic nanoparticles, can be engineered according to their intended uses in cancer immunotherapy. Notably, nature-derived nanoparticles have emerged as a new class of immunotherapeutics. In this review, we describe state-of-the-art strategies for cancer immunotherapy using designed nanoparticles. We also highlight key translational challenges and opportunities in this rapidly growing field. (C) 2017 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD ANTIGEN-PRESENTING CELLS ENGINEERED T-CELLS DENDRITIC CELLS TUMOR-ANTIGENS TGF-BETA SHAPE DEPENDENCE MESSENGER-RNA EXOSOMES DELIVERY VACCINES Harnessing designed nanoparticles: Current strategies and future perspectives in cancer immunotherapy Article 10.1016/j.nantod.2017.10.008 1 NANO TODAY, v.17, pp.23 - 37 NANO TODAY 17 23 37 scie scopus 000418976500009 2-s2.0-85033214457 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Review ANTIGEN-PRESENTING CELLS ENGINEERED T-CELLS DENDRITIC CELLS TUMOR-ANTIGENS TGF-BETA SHAPE DEPENDENCE MESSENGER-RNA EXOSOMES DELIVERY VACCINES Cancer immunotherapy Nanoparticles Targeted delivery Drug delivery system Vaccines Tumor immune evasion Exosome