Shin, Jae Moon Lim, Wooyoung Lee, Kyung-Mi Won, Jung Im Jung, Da Woon Nho, Chu Won Kang, Kui Dong Yoon, Jee Hee Cho, Yoon Shin 2024-01-20T00:02:15Z 2024-01-20T00:02:15Z 2021-09-03 2017-12 1976-9571 https://pubs.kist.re.kr/handle/201004/122007 MicroRNAs (miRNA) of approximately 22 nucleotides are fundamental molecules in cellular biology that act by modulating target gene expression. As a post-transcriptional/translational regulator, the role of miRNAs in human disease is highly expected. Recently, a rising number of miRNAs that are associated with a variety of human diseases have been reported in the literature. Aiming to provide a comprehensive of resource of miRNAs that are related to the human disease, we built the Disease miRNA Database (Disease-miRNAdb). MiRNAs from three groups of diseases including kidney disease, cancer, and metabolic disease were manually curated in the current version of database located on a user-friendly online website (http://disease-miRNAdb.hallym.ac.kr). In addition, this database also includes information regarding single nucleotide polymorphisms (SNPs) located in pre-miRNAs, miRNA flanking regions, and 3'-UTRs of miRNA target genes. The generation of genetic variation in these regions may result in a loss or gain of miRNA-target gene interactions, which may influence the development of disease. Thus, information regarding miRNA-related SNPs will be useful in the discovery of disease-associated miRNAs in human populations by employing SNP association analysis for the disease of interest. Disease-miRNAdb will be continually maintained with up-to-date information to provide a current and valuable resource for investigating the roles of miRNAs in human disease. English SPRINGER ASSOCIATION Disease-miRNAdb: a manually-curated database for the investigation of the microRNA-human disease relationship Article 10.1007/s13258-017-0628-2 1 GENES & GENOMICS, v.39, no.12, pp.1419 - 1424 GENES & GENOMICS 39 12 1419 1424 scie scopus kci ART002292622 000416468400012 2-s2.0-85034015114 Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Genetics & Heredity Article ASSOCIATION MicroRNA MicroRNA target gene Diseases Database Single nucleotide polymorphism