Jegal, Jonghwan Park, No-June Bong, Sim-Kyu Jegal, Hyun Kim, Su-Nam Yang, Min Hye 2024-01-20T00:02:16Z 2024-01-20T00:02:16Z 2021-09-03 2017-12 2072-6643 https://pubs.kist.re.kr/handle/201004/122008 Dioscorea quinqueloba has been used for food substances, as well as in herbal medicines for allergic diseases such as asthma. This study aimed to investigate the anti-atopic dermatitis (AD) effects of the total extract of D. quinqueloba rhizomes and active fractionson murine oxazolone- and 2,4-dinitrochlorobenzene-induced models of AD. Specific AD symptoms, such as erythema, ear swelling, and epidermis thickening, were significantly reduced in the oxazolone-mediated AD BALB/c mice upon topical application of D. quinqueloba rhizomes 95% EtOH extract (DQ). DQEA (D. quinqueloba rhizomes EtOAc fraction) was beneficial for protecting the skin barrier against AD in DNCB-sensitized SKH-1 hairless mice. Decreased total serum IgE and IL-4 levels could be observed in atopic dorsal skin samples of the DQEA-treated group. On the basis of the phytochemical analysis, DQEA was found to contain dioscin and gracillin as its main compounds. Therapeutic applications with D. quinqueloba might be useful in the treatment of AD and related inflammatory skin diseases. English MDPI SKIN BARRIER FUNCTION CONTACT HYPERSENSITIVITY JUNIPERUS-CHINENSIS HAIRLESS MOUSE DISEASE EXPRESSION MICE PREVALENCE OPPOSITA EXTRACT Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models Article 10.3390/nu9121324 1 NUTRIENTS, v.9, no.12 NUTRIENTS 9 12 scie scopus 000419188600049 2-s2.0-85037630030 Nutrition & Dietetics Nutrition & Dietetics Article SKIN BARRIER FUNCTION CONTACT HYPERSENSITIVITY JUNIPERUS-CHINENSIS HAIRLESS MOUSE DISEASE EXPRESSION MICE PREVALENCE OPPOSITA EXTRACT Dioscorea quinqueloba atopic dermatitis transepidermal water loss skin hydration interleukin 4 immunoglobulin E