Kim, Chang-Su Kim, Jin-Hee Kim, Bokyoung Park, Young-Seok Kim, Hong-Kyun Hieu Trung Tran Kim, Sang Hoon Jeon, Hojeong Kim, Sangjib Sim, Ji Hyun Shin, Hyun Mu Kim, Gwanghun Baik, Young Joo Lee, Kee-Joon Kim, Hae-Young Yun, Tae Jin Kim, Youn Sang Kim, Hang-Rae 2024-01-20T00:02:57Z 2024-01-20T00:02:57Z 2021-09-03 2017-11 1616-301X https://pubs.kist.re.kr/handle/201004/122044 Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ-2 and AZ-4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical-sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices. English John Wiley & Sons Ltd. A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation Article 10.1002/adfm.201703569 1 Advanced Functional Materials, v.27, no.44 Advanced Functional Materials 27 44 N scie scopus 000416035400011 2-s2.0-85030630044 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article MESENCHYMAL STEM-CELLS IN-VITRO BONE-FORMATION OSTEOGENIC DIFFERENTIATION SURFACE MICROTOPOGRAPHY EXTRACELLULAR-MATRIX MC3T3-E1 CELLS ASCORBIC-ACID TOPOGRAPHY COLLAGEN bone regeneration groove pattern inflammation osteoblast reactive oxygen species