Kim, Han-Jun Heo, Dong Nyoung Lee, Yi Jae Lee, Sang Jin Kang, Ji Yoon Lee, Soo Hyun Kwon, Ii Keun Do, Sun Hee 2024-01-20T00:03:30Z 2024-01-20T00:03:30Z 2021-09-03 2017-11-10 2045-2322 https://pubs.kist.re.kr/handle/201004/122073 The implantable cuff electrode is an effective neuroprosthetic device in current nerve tissue engineering. However, biocompatibility and stability are still a serious dispute in terms of in vivo function and continuous monitoring. In this regard, assessing the host's biological response to biomaterials is one of the key factors of chronic implantation. In this article, we analyzed the peripheral nerve specific-biological responses to the application of multi-functional hydrogel-coated electrodes. The surface of the cuff electrode was modified using a multifunctional hydrogel composed of PEG hydrogel, cyclosporin A(CsA)-microsphere(MS) and electrodeposited PEDOT:PSS. Through our approach, we have found that the multifunctional hydrogel coatings improve the neural electrode function, such as peak-to-peak amplitude increase. Additionally, the multifunctional hydrogel coated electrodes exhibited improved biocompatibility, such as reduced apoptotic properties and increased axonal myelination. Furthermore, 12 genes (BDNF, Gfra1, IL-6, Sox 10, S100B, P75(NTR), GAP43, MBP, MPZ, NrCAM, NE-FL, CB1) were upregulated at 5 weeks post-implant. Finally, double immunofluorescence revealed the effect of endocannabinoid system on neuroprotective properties and tissue remodeling of peripheral nerves during cuff electrode implantation. These results clearly confirmed that multifunctional hydrogel coatings could improve electrode function and biocompatibility by enhancing neuroprotective properties, which may provide a valuable paradigm for clinical neurology application. English NATURE PUBLISHING GROUP GENE-EXPRESSION CANNABINOID RECEPTOR-1 CONTROLLED-RELEASE NERVOUS-SYSTEM DEXAMETHASONE RECORDINGS CYCLOSPORINE MECHANISMS COATINGS GANGLION Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application Article 10.1038/s41598-017-15551-x 1 SCIENTIFIC REPORTS, v.7 SCIENTIFIC REPORTS 7 scie scopus 000414917000011 2-s2.0-85033564282 Multidisciplinary Sciences Science & Technology - Other Topics Article GENE-EXPRESSION CANNABINOID RECEPTOR-1 CONTROLLED-RELEASE NERVOUS-SYSTEM DEXAMETHASONE RECORDINGS CYCLOSPORINE MECHANISMS COATINGS GANGLION implantable neural electrode biological assessments drug delivery microparticle