Lee, Sullim Lee, Da-Hye Kim, Jin-Chul Um, Byung Hun Sung, Sang Hyun Jeong, Lak Shin Kim, Yong Kee Kim, Su-Nam 2024-01-20T00:03:37Z 2024-01-20T00:03:37Z 2021-09-03 2017-11-04 0006-291X https://pubs.kist.re.kr/handle/201004/122079 Pectolinarin and pectolinarigenin have been reported to be major compounds in Cirsium setidens. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from C. setidens on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in C setidens water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of C setidens water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in C setidens water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method. (C) 2017 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE CIRSIUM-JAPONICUM DC SKIN PIGMENTATION MELANIN CELLS ULTRAVIOLET TYROSINASE EXTRACT FLAVONE Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin Article 10.1016/j.bbrc.2017.08.106 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.493, no.1, pp.765 - 772 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 493 1 765 772 scie scopus 000413134200118 2-s2.0-85028658460 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article CIRSIUM-JAPONICUM DC SKIN PIGMENTATION MELANIN CELLS ULTRAVIOLET TYROSINASE EXTRACT FLAVONE Whitening Melanogenesis Cirsium setidens Microwave Pectolinarin Pectolinarigenin