Jeong, Eun Ju Jegal, Jonghwan Chung, Ki Wung Noh, Sang Gyun Chung, Hae Young Nam, Youn Hee Kang, Tong Ho Kim, Su-Nam Yang, Min Hye 2024-01-20T00:04:17Z 2024-01-20T00:04:17Z 2021-09-03 2017-11 1934-578X https://pubs.kist.re.kr/handle/201004/122116 Hypolaetin-7-O-beta-D-xyloside (1) is a naturally occurring flavonoid from Juniperus communis fruits. This study aimed to investigate anti-melanogenic effect of hypolaetin-7-O-beta-D-xyloside on zebrafish pigmentation. The phenotype-based image analysis suggested that 1 suppressed the zebrafish pigmentation in a concentration-dependent manner (1-400 mu M) as a reversible competitive inhibitor against the enzyme tyrosinase. According to the molecular docking simulation, the compound 1 interacted with residues His-263 of tyrosinase via hydrogen bonding. The present study provided direct experimental evidence for skin-lightening effect of 1 in an in vivo zebrafish model. Therapeutic attempts with the 1 might be useful in the management of skin pigmentation-related diseases. English SAGE PUBLICATIONS INC Hypolaetin-7-O-β-D-xyloside from Juniperus communis Fruits Inhibits Melanogenesis on Zebrafish Pigmentation Article 10.1177/1934578X1701201107 1 Natural Product Communications, v.12, no.11, pp.1687 - 1690 Natural Product Communications 12 11 1687 1690 N scie scopus 000417552000006 2-s2.0-85035190797 Chemistry, Medicinal Food Science & Technology Pharmacology & Pharmacy Food Science & Technology Article MUSHROOM TYROSINASE SKIN MECHANISM PLANTS Hypolaetin-7-O-beta-D-xyloside Anti-melanogenesis Zebrafish pigmentation Tyrosinase inhibitor Molecular docking