Kwon, Koo Chul Jo, Eunji Kwon, Young-Wan Lee, Boram Ryu, Ju Hee Lee, Eun Jung Kim, Kwangmeyung Lee, Jeewon 2024-01-20T00:30:44Z 2024-01-20T00:30:44Z 2021-09-03 2017-10-11 0935-9648 https://pubs.kist.re.kr/handle/201004/122175 Cancer theragnosis using a single multimodality agent is the next mainstay of modern cancer diagnosis, treatment, and management, but a clinically feasible agent with in vivo cancer targeting and theragnostic efficacy has not yet been developed. A new type of cancer theragnostic agent is reported, based on gold magnetism that is induced on a cancer-targeting protein particle carrier. Superparamagnetic gold-nanoparticle clusters (named SPAuNCs) are synthesized on a viral capsid particle that is engineered to present peptide ligands targeting a tumor cell receptor (TCR). The potent multimodality of the SPAuNCs is observed, which enables TCR-specific targeting, T-2-weighted magnetic resonance imaging, and magnetic hyperthermia therapy of both subcutaneous and deep-tissue tumors in live mice under an alternating magnetic field. Furthermore, it is analytically elucidated how the magnetism of the SPAuNCs is sufficiently induced between localized and delocalized spins of Au atoms. In particular, the SPAuNCs show excellent biocompatibility without the problem of in vivo accumulation and holds promising potential as a clinically effective agent for cancer theragnosis. English WILEY-V C H VERLAG GMBH MAGNETIC-RESONANCE TOXICITY FUNCTIONALIZATION PERMANENT PEPTIDES COMPLEX DESIGN Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis Article 10.1002/adma.201701146 1 ADVANCED MATERIALS, v.29, no.38 ADVANCED MATERIALS 29 38 scie scopus 000412452500007 2-s2.0-85026369132 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article MAGNETIC-RESONANCE TOXICITY FUNCTIONALIZATION PERMANENT PEPTIDES COMPLEX DESIGN cancer targeting cancer theragnosis magnetic hyperthermia therapy magnetic resonance imaging (MRI) superparamagnetic gold nanoparticles