Lee, Yong-Jik Jang, Yoo-Na Han, Yoon-Mi Kim, Hyun-Min Jeong, Jong-Min Son, Min Jeoung Jin, Chang Bae Kim, Hyoung Ja Seo, Hong Seog 2024-01-20T00:31:20Z 2024-01-20T00:31:20Z 2021-09-05 2017-10 1687-4757 https://pubs.kist.re.kr/handle/201004/122208 Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue. Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with A. glehni. Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor delta, 5' adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPAR gamma coactivator 1-alpha in liver tissues increased in the groups treated with A. glehni. Conversely, protein levels of ATP citrate lyase, fatty acid synthase, tumor necrosis factor alpha, and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon A. glehni. Triglyceride concentration in the liver was lower in mice treated with A. glehni than in control mice. Lipid accumulation in HepG2 and 3T3-L1 cells decreased upon A. glehni treatment; this effect was suppressed in the presence of the PPAR delta antagonist, GSK0660. Our findings suggest that A. glehni extracts may ameliorate NAFLD through regulation of PPAR delta, adiponectin, and the related subgenes. English HINDAWI LTD ACTIVATED PROTEIN-KINASE ATP-CITRATE LYASE SKELETAL-MUSCLE OXIDATIVE STRESS GENE-EXPRESSION IN-VITRO DISEASE GLUCOSE ALPHA ASSOCIATION Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPAR delta and Adiponectin in ApoE KO Mice Article 10.1155/2017/3912567 1 PPAR RESEARCH, v.2017 PPAR RESEARCH 2017 scie scopus 000432563300001 2-s2.0-85042480289 Medicine, Research & Experimental Research & Experimental Medicine Article ACTIVATED PROTEIN-KINASE ATP-CITRATE LYASE SKELETAL-MUSCLE OXIDATIVE STRESS GENE-EXPRESSION IN-VITRO DISEASE GLUCOSE ALPHA ASSOCIATION Aster glehni Nonalcoholic fatty liver disease Caffeoylquinic Acid-Rich Extract ApoE KO Mice