Jang, Holim Srichayet, Phisamai Park, Woo Jung Heo, Ho Jin Kim, Dae-Ok Tongchitpakdee, Sasitorn Kim, Tae-Jin Jung, Sang Hoon Lee, Chang Yong 2024-01-20T00:31:39Z 2024-01-20T00:31:39Z 2021-09-05 2017-10 1756-4646 https://pubs.kist.re.kr/handle/201004/122225 This study was to evaluate the protective effect of Phyllanthus emblica L. (Indian gooseberry) on retinal degeneration in a well-characterized animal model of Alzheimer's disease. RGC-5 cells were treated with Indian gooseberry extract (IGE), and intracellular antioxidant activity was evaluated. IGE was orally administered to mice for 21 days, then amyloid beta (All) was administered by intracerebroventricular injection to induce neuronal damage in the brain and retina, and enucleated eyes were collected from the mice and analyzed using western blots and histological assays. As a result, we found that IGE inhibited intracellular oxidative stress and reduced the severity of histological changes caused by A(3-induced retinal degeneration in retinal tissue. Furthermore, it regulated the levels of neurofilament (NF)-L, thymocyte differentiation antigen 1 (Thy-1), and sirtuin 1 (SIRT1) in the retina. These findings demonstrate that IGE protects against retinal degeneration and suggest that this effect is attributable to its antioxidant properties. (C) 2017 Elsevier Ltd. All rights reserved. English ELSEVIER CELL-DEATH OFFICINALIS GAERTN. LAYER THICKNESS GANGLION-CELLS INDUCED DAMAGE ANTIOXIDANT SIRT1 CYANIDIN-3-GLUCOSIDE ABNORMALITIES ANTHOCYANINS Phyllanthus emblica L. (Indian gooseberry) extracts protect against retinal degeneration in a mouse model of amyloid beta-induced Alzheimer's disease Article 10.1016/j.jff.2017.07.056 1 JOURNAL OF FUNCTIONAL FOODS, v.37, pp.330 - 338 JOURNAL OF FUNCTIONAL FOODS 37 330 338 scie scopus 000412863400033 2-s2.0-85029912974 Food Science & Technology Nutrition & Dietetics Food Science & Technology Nutrition & Dietetics Article CELL-DEATH OFFICINALIS GAERTN. LAYER THICKNESS GANGLION-CELLS INDUCED DAMAGE ANTIOXIDANT SIRT1 CYANIDIN-3-GLUCOSIDE ABNORMALITIES ANTHOCYANINS Indian gooseberry Retinal degeneration Alzheimer&apos s disease Amyloid beta