Noh, Joo-Yoon Kim, Jo-Il Chang, Young Wook Park, Jong-Min Song, Hyun-Woo Kang, Min-Jung Pyun, Jae-Chul 2024-01-20T00:32:30Z 2024-01-20T00:32:30Z 2021-09-05 2017-09-20 1976-0280 https://pubs.kist.re.kr/handle/201004/122269 Gold nanoislands chip were developed as a solid matrix for the analysis of small molecules using laser desorption/ionization time-of-flight (LDI-ToF) mass spectrometry substituting the organic matrices which usually produce strong noise at low mass to-charge ratio range (m/z <500). Gold nanoislands were simply prepared by (1) deposition of gold layer on highly P-doped silicon substrate followed by (2) heating. Physical properties-of the gold nanoislands were analyzed by scanning electron microscope (SEM), atomic force microscopy (AFM) analysis to characterize the morphology, diameter, thickness, and surface density of the nanoislands which were comparatively analyzed in conjunction with LDI-ToF mass spectrometry. In this work, optimal size of the nanoislands were selected for LDI-ToF mass spectrometry, and gold nanoislands chip were applied to the quantitative and simultaneous detection of small analytes (amino acids) with various chemical and physical properties (polar, nonpolar, acidic, and basic). English KOREAN BIOCHIP SOCIETY-KBCS SURFACE-PLASMON RESONANCE PHOTOCATALYTIC ACTIVITY SOLID-MATRIX SALDI-MS NANOPARTICLES IONIZATION DESORPTION FILMS MOLECULES PEPTIDES Gold Nanoislands Chip for Laser Desorption/Ionization (LDI) Mass Spectrometry Article 10.1007/s13206-017-1310-0 1 BIOCHIP JOURNAL, v.11, no.3, pp.246 - 254 BIOCHIP JOURNAL 11 3 246 254 scie scopus kci ART002263126 000411542100010 2-s2.0-85038088195 Biochemical Research Methods Chemistry, Analytical Nanoscience & Nanotechnology Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Article SURFACE-PLASMON RESONANCE PHOTOCATALYTIC ACTIVITY SOLID-MATRIX SALDI-MS NANOPARTICLES IONIZATION DESORPTION FILMS MOLECULES PEPTIDES Gold nanoislands Solid matrix LDI-ToF mass spectrometry Amino acids Localized surface plasmon resonance