Kim, Taegon Yamamoto, Yukio Tanaka-Yamamoto, Keiko 2024-01-20T00:34:01Z 2024-01-20T00:34:01Z 2021-09-05 2017-09 2041-1723 https://pubs.kist.re.kr/handle/201004/122350 An important feature of long-term synaptic plasticity is the prolonged maintenance of plastic changes in synaptic transmission. The trafficking of AMPA-type glutamate receptors (AMPARs) is involved in the expression of many forms of synaptic plasticity, yet the subsequent events accomplishing the maintenance of plastic changes in synaptic AMPAR numbers are not fully understood. Here, we find that maintenance of cerebellar long-term depression results from a reduction in the number of AMPARs residing within endocytic recycling pathways. We then develop a genetically encoded, photosensitive inhibitor of late endosome sorting and use this to discover that initial maintenance of long-term depression relies on timely regulated late endosome sorting, which exhibits a threshold as well as switch-like behavior. Thus, our results indicate that recycling AMPAR numbers are reduced by a switching machinery of transient late endosome sorting, and that this process enables the transition from basal synaptic transmission to long-term depression maintenance. English Nature Publishing Group Timely regulated sorting from early to late endosomes is required to maintain cerebellar long-term depression Article 10.1038/s41467-017-00518-3 1 Nature Communications, v.8 Nature Communications 8 Y scie scopus 000408820700001 2-s2.0-85028684027 Multidisciplinary Sciences Science & Technology - Other Topics Article AMPA RECEPTOR TRAFFICKING PROTEIN-KINASE-C PURKINJE-CELLS SIGNAL-TRANSDUCTION MEDIATED ENDOCYTOSIS SYNAPTIC PLASTICITY GRANULE CELLS RAB PROTEINS LATE-PHASE EXPRESSION