Kwon, Jaeyoung Lee, H. Kim, N. Lee, J.-H. Woo, M.H. Kim, J. Kim, Y.S. Lee, D. 2024-01-20T00:34:35Z 2024-01-20T00:34:35Z 2021-08-31 2017-09 0253-6269 https://pubs.kist.re.kr/handle/201004/122381 Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC？ELSD method was developed for the quantification of PD in various states of 73 P. grandiflorum root samples from East Asia, and it exhibited a marked variation of the content. Furthermore, the effects of processing procedures such as peeling and drying temperature on the PD content were investigated using UPLC？ELSD analysis, and as a result, a significant influence of processing methods such as peeling and heating of samples on the content was confirmed. Specifically, unpeeled samples that were dried at 40？°C showed the greatest PD content. The obtained results could facilitate the reliable standardization of P. grandiflorum for precise authentication and efficacious applications. ？ 2017, The Pharmaceutical Society of Korea. English Pharmaceutical Society of Korea Effect of processing method on platycodin D content in Platycodon grandiflorum roots Article 10.1007/s12272-017-0946-6 1 Archives of Pharmacal Research, v.40, no.9, pp.1087 - 1093 Archives of Pharmacal Research 40 9 1087 1093 N scie scopus kci ART002263793 000411863500008 2-s2.0-85028745242 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article plant medicinal product platycodin D unclassified drug platycodin D saponin triterpene Article controlled study drug determination drug structure heating nonhuman plant root Platycodon processing temperature chemistry Far East high performance liquid chromatography isolation and purification procedures validation study Chromatography, High Pressure Liquid Far East Plant Roots Platycodon Saponins Temperature Triterpenes HPLC？ELSD Platycodi Radix Platycodin D Platycodon grandiflorum Processing method