Hwang, Ji Sun Kim, Geum Jin Choi, Hyun Gyu Kim, Min Cheol Hahn, Dongyup Nam, Joo-Won Nam, Saug-Jip Kwon, Hak Choel Chin, Jungwook Cho, Sung Jin Hwang, Hayoung Choi, Hyukjae 2024-01-20T01:01:07Z 2024-01-20T01:01:07Z 2022-01-25 2017-08 0163-3864 https://pubs.kist.re.kr/handle/201004/122441 Angiogenesis is the process of new blood vessel formation. Excessive angiogenesis is a critical factor in the progression of cancer, macular degeneration, and other chronic inflammatory diseases. When investigating the effects of crude extracts of cultured marine microorganisms, an extract of the cultured Streptomyces sp. YP127 strain was found to inhibit human umbilical vein endothelial cell (HUVEC) tube formation. Bioassay-guided fractionation and spectroscopic data analyses led to the identification of napyradiomycin A1 (1) as an antiangiogenic component of the extract. Compound 1 inhibited HUVEC tube formation in a concentration-dependent manner. It inhibited endothelial cell proliferation but did not affect human dermal fibroblast proliferation. Compound 1 also suppressed migration and invasion of vascular endothelial cells. In addition, compound 1 suppressed vascular endothelial cadherin expression and increased the permeability of the endothelial cell membrane. These results suggested that compound 1 modulates cell permeability and inhibits the angiogenesis of endothelial cells. English AMER CHEMICAL SOC Identification of Antiangiogenic Potential and Cellular Mechanisms of Napyradiomycin A1 Isolated from the Marine-Derived Streptomyces sp YP127 Article 10.1021/acs.jnatprod.7b00211 1 JOURNAL OF NATURAL PRODUCTS, v.80, no.8, pp.2269 - 2275 JOURNAL OF NATURAL PRODUCTS 80 8 2269 2275 N scie scopus 000408702600010 2-s2.0-85028567542 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article VE-CADHERIN ANTIBIOTICS NAPYRADIOMYCINS CHRONIC INFLAMMATION ANGIOGENESIS CANCER DISCOVERY CARCINOMA THERAPY TARGET