Kim, Yoo Sung Woo, Junsung Lee, C. Justin Yoon, Bo-Eun 2024-01-20T01:01:33Z 2024-01-20T01:01:33Z 2021-09-05 2017-08 1226-2560 https://pubs.kist.re.kr/handle/201004/122466 About 5 similar to 12% of school-aged children suffer from the Attention-Deficit/Hyperactivity Disorder (ADHD). However, the core mechanism of ADHD remains unclear. G protein-coupled receptor kinase-interacting protein-1 (GIT1) has recently been reported to be associated with ADHD in human and the genetic deletion of GIT1 result in ADHD-like behaviors in mice. Mice lacking GIT1 shows a shift in neuronal excitation/inhibition (E/I) balance. However, the pricise mechanism for E/I imbalance and the role of neuron-glia interaction in GIT1 knockout (KO) mice have not been studied. Especially, a possible contribution of glial GABA and tonic inhibition mediated by astrocytic GABA release in the mouse model for ADHD remains unexplored. Therefore, we investigated the changes in the amount of GABA and degree of tonic inhibition in GIT1 KO mice. We observed a decreased glial GABA intensity in GIT1 KO mice compared to wild type (WT) mice and an attenuation of tonic current from cerebellar granule cells in GIT1 KO mice. Our study identifies the previously unknown mechanism of reduced astrocytic GABA and tonic inhibition in GIT1 lacking mice as a potential cause of hyperactivity disorder. English KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE DEFICIT HYPERACTIVITY DISORDER BRAIN-DEVELOPMENT ANIMAL-MODELS BASAL GANGLIA MOTOR MICE Decreased Glial GABA and Tonic Inhibition in Cerebellum of Mouse Model for Attention-Deficit/Hyperactivity Disorder (ADHD) Article 10.5607/en.2017.26.4.206 1 EXPERIMENTAL NEUROBIOLOGY, v.26, no.4, pp.206 - 212 EXPERIMENTAL NEUROBIOLOGY 26 4 206 212 scie scopus kci ART002258870 000424431900004 2-s2.0-85029321447 Medicine, Research & Experimental Neurosciences Research & Experimental Medicine Neurosciences & Neurology Article DEFICIT HYPERACTIVITY DISORDER BRAIN-DEVELOPMENT ANIMAL-MODELS BASAL GANGLIA MOTOR MICE ADHD GIT1 tonic inhibition glia astrocyte GABA