Kim, Youngjun Kwon, Chunga Jeon, Hojeong 2024-01-20T01:01:39Z 2024-01-20T01:01:39Z 2021-09-05 2017-08 https://pubs.kist.re.kr/handle/201004/122471 A micro-patterned cell adhesive surface was prepared for future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro-patterns were prepared by a photolithography process. Afterwards, recombinant filamentous phages that displayed a short binding motif with a cell adhesive peptide (-RGD-) on p8 proteins were immobilized on PDMS microgrooves through simple contact printing to study the cellular response of rat H9c2 cardiomyocyte. While the cell density decreased on PDMS micro-patterns, we observed enhanced cell proliferation and cell to surface interaction on the RGD-phage coated PDMS microgrooves. The RGD-phage coating also supported a better alignment of cell spreading rather than isotropic cell growths as we observed on non-pattered PDMS surface. English MDPI Open Access Publishing Genetically Engineered Phage Induced Selective H9c2 Cardiomyocytes Patterning in PDMS Microgrooves Article 10.3390/ma10080973 1 Materials, v.10, no.8 Materials 10 8 Y scie scopus 000408731600127 2-s2.0-85027685621 Chemistry, Physical Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Physics, Applied Physics, Condensed Matter Chemistry Materials Science Metallurgy & Metallurgical Engineering Physics Article PROLIFERATION SURFACES SCAFFOLDS ALIGNMENT SCALE CELLS polydimethylsiloxane (PDMS) micro-patterns RGD-phage cell-surface interaction rat H9c2 cardiomyocytes