Hassan, Shabir Prakash, Gyan Ozturk, Ayca Bal Saghazadeh, Saghi Sohail, Muhammad Farhan Seo, Jungmok Dokmeci, Mehmet Remzi Zhang, Yu Shrike Khademhosseini, Ali 2024-01-20T01:01:55Z 2024-01-20T01:01:55Z 2021-09-04 2017-08 1748-0132 https://pubs.kist.re.kr/handle/201004/122486 With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rate and bio-distribution still exist, thus making their successful translation to clinical application very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review, the stress has been made on the evolution of nanomaterials that are under different stages of clinical trials or have been approved by the United States Food and Drug Administration (FDA). (C) 2017 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD IRON-OXIDE NANOPARTICLES QUANTUM DOTS GOLD NANOPARTICLES INORGANIC NANOPARTICLES POLYMERIC MICELLES LIPOSOMAL DOXORUBICIN CONTROLLED-RELEASE PROTEIN DELIVERY CANCER-CELLS PHASE-II Evolution and clinical translation of drug delivery nanomaterials Article 10.1016/j.nantod.2017.06.008 1 NANO TODAY, v.15, pp.91 - 106 NANO TODAY 15 91 106 scie scopus 000411546200011 2-s2.0-85026632563 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Review IRON-OXIDE NANOPARTICLES QUANTUM DOTS GOLD NANOPARTICLES INORGANIC NANOPARTICLES POLYMERIC MICELLES LIPOSOMAL DOXORUBICIN CONTROLLED-RELEASE PROTEIN DELIVERY CANCER-CELLS PHASE-II Drug delivery Inorganic nanomaterial Polymeric nanomaterial Liposomes Clinical trials FDA approval