Lee, Dahae Kim, Taejung Kim, Ki Hyun Ham, Jungyeob Jang, Tae Su Kang, Ki Sung Lee, Jae Wook 2024-01-20T01:02:33Z 2024-01-20T01:02:33Z 2021-09-05 2017-07-15 0960-894X https://pubs.kist.re.kr/handle/201004/122520 Guggulsterone derivatives were prepared using [3+2] click chemistry with aryl and alkyl acetylene. The series of derivatives were evaluated for their cellular protective effects on cisplatin-treated cultured LLC-PK1 kidney epithelial cells. Among the guggulsterone-triazole derivatives, compound 6g, which contains a hydroxyl methyl group, was the most active of all the derivatives. In an additional study, we determined that inhibition of the mitogen-activated protein kinase/caspase-3 signaling cascade by 6g mediates its protective effects against cytotoxicity in cultured LLC-PK1 cells. (C) 2017 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. NF-KAPPA-B OXIDATIVE STRESS NATURAL PRODUCT IN-VITRO ANTAGONIST DISEASE TRANSCRIPTION CONSTITUENT ACTIVATION GINSENG Evaluation of guggulsterone derivatives as novel kidney cell protective agents against cisplatin-induced nephrotoxicity Article 10.1016/j.bmcl.2017.05.033 1 Bioorganic & Medicinal Chemistry Letters, v.27, no.14, pp.3156 - 3161 Bioorganic & Medicinal Chemistry Letters 27 14 3156 3161 scie scopus 000404422000024 2-s2.0-85019871777 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article NF-KAPPA-B OXIDATIVE STRESS NATURAL PRODUCT IN-VITRO ANTAGONIST DISEASE TRANSCRIPTION CONSTITUENT ACTIVATION GINSENG Guggulsterone Kidney protection Click chemistry MAPK