Yi, Chae-Min Yu, Jihyun Kim, Hyunbin Lee, Na-Rae Kim, Sang Won Lee, Noh-Jin Lee, Jun Seong, Jihye Kim, Nam-Jung Inn, Kyung-Soo 2024-01-20T01:02:55Z 2024-01-20T01:02:55Z 2021-09-04 2017-07-04 1359-7345 https://pubs.kist.re.kr/handle/201004/122541 Despite the diverse pharmacological activities of berberine, including anti-cancer and anti-inflammatory effects, the direct proteomic targets of berberine have remained largely unknown. Here, we have identified actin as a direct proteomic target of berberine using an affinity-based chemical probe. In addition, we found that actin assembly was significantly modulated by berberine in vitro at the biochemical level and cellular level. English ROYAL SOC CHEMISTRY CELLULAR TARGETS DERIVATIVES QUADRUPLEX BINDING PERSPECTIVES METAANALYSIS MECHANISMS RHIZOMA TRIALS CANCER Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly Article 10.1039/c7cc02789c 1 CHEMICAL COMMUNICATIONS, v.53, no.52, pp.7045 - 7047 CHEMICAL COMMUNICATIONS 53 52 7045 7047 scie scopus 000404466200015 2-s2.0-85021778099 Chemistry, Multidisciplinary Chemistry Article CELLULAR TARGETS DERIVATIVES QUADRUPLEX BINDING PERSPECTIVES METAANALYSIS MECHANISMS RHIZOMA TRIALS CANCER