Eom, Taejun Yoo, Wonjae Lee, Yong-Deok Park, Jae Hyung Choe, Youngson Bang, Joona Kim, Sehoon Khan, Anzar 2024-01-20T01:04:13Z 2024-01-20T01:04:13Z 2021-09-05 2017-06-28 2050-7518 https://pubs.kist.re.kr/handle/201004/122609 Triggered cellular uptake of a synthetic graft copolymer carrying an anticancer drug is achieved through self-immolation of the side-chain azobenzene groups. In this concept, the conjugate is initially chemically neutral and does not possess cell-penetrating function. However, upon cleavage of the azobenzene moieties, a cascade process is initiated that ultimately reveals an ammonium cation in the vicinity of the polymer backbone. Hence, self-immolation results in the transformation of the neutral polymer chain into a polycation. This structural transformation allows the conjugate to be taken up by the cancer cells through favorable electrostatic interactions with the negatively charged phospholipid components of the cell membrane. Once inside the cells, the polymer releases covalently attached doxorubicin in a pristine form through a low pH activated release mechanism. The significance of this approach lies in the sensitivity of the azobenzene group to hypoxic conditions and to the enzyme azoreductase that is secreted by the microbial flora of the human colon and suggests a pathway to targeted drug delivery applications under these conditions. English ROYAL SOC CHEMISTRY CELL-PENETRATING PEPTIDES AZO-DYES ENZYME MICELLES DELIVERY REDUCTION RELEASE SYSTEMS PROBES ACID An activatable anticancer polymer-drug conjugate based on the self-immolative azobenzene motif Article 10.1039/c7tb01250k 1 JOURNAL OF MATERIALS CHEMISTRY B, v.5, no.24, pp.4574 - 4578 JOURNAL OF MATERIALS CHEMISTRY B 5 24 4574 4578 scie scopus 000404070600003 2-s2.0-85021719226 Materials Science, Biomaterials Materials Science Article CELL-PENETRATING PEPTIDES AZO-DYES ENZYME MICELLES DELIVERY REDUCTION RELEASE SYSTEMS PROBES ACID