Park, Do Yeun Park, Jisoo Jang, Heeyeong Cheng, Jie Kim, Soo Hyun Lee, Sang-Hoon 2024-01-20T01:30:33Z 2024-01-20T01:30:33Z 2021-09-04 2017-06-01 1758-5082 https://pubs.kist.re.kr/handle/201004/122653 Microfibers produced using electrospinning and microfluidics-based technologies have been developed as a powerful tool in tissue engineering applications such as drug delivery and scaffolds. The applications of these fibers, however, have been limited because of the hazardous solvents used to make them, difficulties in controlling the pore sizes of their membrane forms, and downscaling the size of the fiber. Nevertheless, extending the use of these fibers, for example in the production of a freestanding porous membrane appropriate for cell-based research, is highly needed for tissue engineering, organ-on-a-chip, and drug delivery research and applications. Here, we fabricated a freestanding porous membrane by using a novel method that involved simultaneously spinning multiple strands of submicron-thick 'noodle-like' fibers. In addition to the novelty of the single noodle fiber in overcoming the size-reducing limitations of conventional microfluidic spinning methods, these fibers can hence form the units of 'noodle membranes' whose pores have sizes that the convention electrospinning method cannot achieve. We confirmed the potential of the noodle membrane to serve as a free-standing porous membrane in two simple experiments. Also, we found that noodle membranes have an advantage in loading different amounts of different materials in itself that it was also shown to be of use as a new type of scaffold for complex tissue regeneration. Therefore, the proposed noodle membrane can be an effective tool in tissue engineering applications and biological studies. English IOP PUBLISHING LTD TISSUE-ENGINEERING APPLICATIONS SOLID-STATE NANOPORE ALGINATE FIBERS CHIP FABRICATION DEVICE REGENERATION GENERATION SCAFFOLDS COLLAGEN Simultaneous microfluidic spinning of multiple strands of submicron fiber for the production of free-standing porous membranes for biological application Article 10.1088/1758-5090/aa7307 1 BIOFABRICATION, v.9, no.2 BIOFABRICATION 9 2 scie scopus 000402913700003 2-s2.0-85022063326 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article TISSUE-ENGINEERING APPLICATIONS SOLID-STATE NANOPORE ALGINATE FIBERS CHIP FABRICATION DEVICE REGENERATION GENERATION SCAFFOLDS COLLAGEN microfiber spinning chip noodle fiber noodle membrane free-standing porous membrane tissue regeneration