Nguyen Tuan Hiep Kwon, Jaeyoung Kim, Dong-Woo Hong, Sungeun Guo, Yuanqiang Hwang, Bang Yeon Kim, Nahyun Mar, Woongchon Lee, Dongho 2024-01-20T01:32:11Z 2024-01-20T01:32:11Z 2021-09-01 2017-05-11 0040-4020 https://pubs.kist.re.kr/handle/201004/122741 Cudraisoflavone L - T (1-11), cudradihydrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC50 values of 4.5-18.6 mu M. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC50 values of 3.5-11.9 mu M. (C) 2017 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CUDRANIA-TRICUSPIDATA NEURODEGENERATIVE DISEASES ABSOLUTE-CONFIGURATION OXIDATIVE STRESS FLAVONOIDS ISOFLAVONES ROOTS ANTIOXIDANT DERIVATIVES DIHYDROFLAVONOLS Neuroprotective constituents from the fruits of Maclura tricuspidata Article 10.1016/j.tet.2017.03.064 1 TETRAHEDRON, v.73, no.19, pp.2747 - 2759 TETRAHEDRON 73 19 2747 2759 scie scopus 000400532000005 2-s2.0-85017062549 Chemistry, Organic Chemistry Article CUDRANIA-TRICUSPIDATA NEURODEGENERATIVE DISEASES ABSOLUTE-CONFIGURATION OXIDATIVE STRESS FLAVONOIDS ISOFLAVONES ROOTS ANTIOXIDANT DERIVATIVES DIHYDROFLAVONOLS Maclura tricuspidata Cudrania tricuspidata Snatzke&apos s method Circular dichroism Neuroprotective activity