Seo, Jeong-Sun Lee, Seungbok Shin, Jong-Yeon Hwang, Yu Jin Cho, Hyesun Yoo, Seong-Keun Kim, Yunha Lim, Sung su Kim, Yun Kyung Hwang, Eun Mi Kim, Su Hyun Kim, Chong-Hyun Hyeon, Seung Jae Yun, Ji-Young Kim, Jihye Kim, Yona Alvarez, Victor E. Stein, Thor D. Lee, Junghee Kim, Dong Jin Kim, Jong-Il Kowall, Neil W. Ryu, Hoon McKee, Ann C. 2024-01-20T01:32:57Z 2024-01-20T01:32:57Z 2021-09-01 2017-05 1226-3613 https://pubs.kist.re.kr/handle/201004/122782 Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury and has distinctive neuropathological features that differentiate this disease from other neurodegenerative diseases. Intraneuronal tau aggregates, although they occur in different patterns, are diagnostic neuropathological features of CTE, but the precise mechanism of tauopathy is not known in CTE. We performed whole RNA sequencing analysis of post-mortem brain tissue from patients with CTE and compared the results to normal controls to determine the transcriptome signature changes associated with CTE. The results showed that the genes related to the MAP kinase and calcium-signaling pathways were significantly downregulated in CTE. The altered expression of protein phosphatases (PPs) in these networks further suggested that the tauopathy observed in CTE involves common pathological mechanisms similar to Alzheimer's disease (AD). Using cell lines and animal models, we also showed that reduced PPP3CA/PP2B phosphatase activity is directly associated with increases in phosphorylated (p)-tau proteins. These findings provide important insights into PP-dependent neurodegeneration and may lead to novel therapeutic approaches to reduce the tauopathy associated with CTE. English 생화학분자생물학회 Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy Article 10.1038/emm.2017.56 1 Experimental & Molecular Medicine, v.49 Experimental & Molecular Medicine 49 N scie scopus kci ART002225423 000404159600007 2-s2.0-85042463110 Biochemistry & Molecular Biology Medicine, Research & Experimental Biochemistry & Molecular Biology Research & Experimental Medicine Article DISEASE EPIDEMIOLOGY CALCINEURIN