Park, Seung-Yoon Kim, In-San 2024-01-20T01:33:05Z 2024-01-20T01:33:05Z 2021-09-01 2017-05 1226-3613 https://pubs.kist.re.kr/handle/201004/122789 The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as 'find-me' and 'eat-me' signals. Engulfment signals are recognized by multiple types of phagocytic machinery in phagocytes, leading to prompt clearance of apoptotic cells. In addition, apoptotic cells and phagocytes release tolerogenic signals to reduce immune responses against apoptotic cell-derived self-antigens. Here we discuss recent advances in our knowledge of engulfment signals, the phagocytic machinery and the signal transduction pathways for apoptotic cell engulfment. English 생화학분자생물학회 Engulfment signals and the phagocytic machinery for apoptotic cell clearance Article 10.1038/emm.2017.52 1 Experimental & Molecular Medicine, v.49 Experimental & Molecular Medicine 49 N scie scopus kci ART002225420 000404159600005 2-s2.0-85019131194 Biochemistry & Molecular Biology Medicine, Research & Experimental Biochemistry & Molecular Biology Research & Experimental Medicine Review PHOSPHATIDYLSERINE RECEPTOR TIM-4 RESIDENT PERITONEAL-MACROPHAGES ADAPTER PROTEIN GULP MER TYROSINE KINASE C-ELEGANS CAENORHABDITIS-ELEGANS MEDIATED PHAGOCYTOSIS SCAVENGER RECEPTOR CORPSE ENGULFMENT CRKII/DOCK180/RAC PATHWAY