Han, Se Hee Chung, Ji Hyung Kim, Joon Kim, Key-Sun Han, Ye Sun 2024-01-20T01:33:10Z 2024-01-20T01:33:10Z 2021-09-01 2017-05 1792-1074 https://pubs.kist.re.kr/handle/201004/122794 Human ribosomal protein S3 (hRpS3) is a component of the 40S ribosomal subunit that associated in protein synthesis. hRpS3 has additional ribosomal functions such as DNA repair, transcription, metastasis, and apoptosis via interaction with numerous signaling molecules and has different modifications. Cyclin-dependent kinases (CDKs) are heterodimeric serine/threonine protein kinases that regulate cell cycle progression. Among its members, the Cdkl-cyclin B complex is known to control cell progression in the G2/M phase, while Cdk2-cyclin EA complexes function in GUS and S/G2 transition. In our previous study, we observed interaction between hRpS3 and Cdkl. The present study investigated the interaction between hRpS3 and Cdk2. Cdk2 phosphorylated hRps3 at amino acid residues S6 and T221 during the S-phase. Furthermore, hRpS3 knockdown delayed cell cycle progression by modulating the expression of cell cycle-related proteins, including cyclin B1 and cyclin El. These findings suggest that hRpS3 is involved in Cdk2-mediated cell cycle regulation. English Spandidos Publications New role of human ribosomal protein S3: Regulation of cell cycle via phosphorylation by cyclin-dependent kinase 2 Article 10.3892/ol.2017.5906 1 Oncology Letters, v.13, no.5, pp.3681 - 3687 Oncology Letters 13 5 3681 3687 N scie scopus 000401129800114 2-s2.0-85017416196 Oncology Oncology Article PROGRESSION DELTA RPS3 CDK2 human ribosomal protein S3 cyclin-dependent kinase 2 cell cycle regulation in vitro kinase assay protein-protein interaction