Chin, Jungwook Hahn, Dongyup Won, Dong Hwan Cho, Sung Jin Kim, Kyung-Hee Ham, Jungyeob Kang, Heonjoong 2024-01-20T01:33:15Z 2024-01-20T01:33:15Z 2021-09-01 2017-05 0253-2964 https://pubs.kist.re.kr/handle/201004/122799 In our attempt to develop a method to synthesize E- and Z-guggulsterones [antagonists of farnesoid X receptor (FXR)], we have succeeded in synthesizing E-guggulsterone selectively from three steroids, viz, 4-androsten-3, 17-dione (2), 5-androsten-3 beta-ol-17-one (DHEA) (3), and testosterone (4), in 68, 86 and 62% overall yield, respectively. We also investigated the biological effects of the synthetic E- and Z-guggulsterones and found that E-guggulsterone was more potent than Z-guggulsterone in inhibiting FXR transactivation English 대한화학회 Regioselective Synthesis of the FXR Antagonist E-Guggulsterone from Three Natural Steroids Article 10.1002/bkcs.11120 1 Bulletin of the Korean Chemical Society, v.38, no.5, pp.525 - 529 Bulletin of the Korean Chemical Society 38 5 525 529 N scie scopus kci ART002223920 000400992200004 2-s2.0-85017462602 Chemistry, Multidisciplinary Chemistry Article SALT EXPORT PUMP X-RECEPTOR BILE STEREOCHEMISTRY CHOLESTEROL PRODUCT CELLS ACTS Guggulsterone Natural steroid Farnesoid X receptor antagonist Lipid disorders Regioselective synthesis