Kim, Hoon Kee Kim, Eunha Jang, Hongje Kim, Young-Kwan Kang, Kyungtae 2024-01-20T01:33:31Z 2024-01-20T01:33:31Z 2021-09-01 2017-05 2199-692X https://pubs.kist.re.kr/handle/201004/122815 This review summarizes recent experimental results regarding the influences of surface nanotopography on stem cell differentiation into neurons and neuronal development. Collections of observations and their interpretations are provided. We specifically focus on the in vivo implications of the results, by suggesting that: (i) neural cells use their intracellular machineries to actively recognize surface nanotopography; (ii) the preferential differentiation of stem cells into neurons and the developmental acceleration of neurons occur on a range of similar nanotopographical features, implying that they have similar biological backgrounds; and (iii) surface nanotopography, therefore, is deeply involved in brain development. We believe that this review will provide biological insights to the field of nanoneuron interfaces and encourage interdisciplinary efforts capable of addressing unsolved biological problems and increasing engineering needs. English WILEY-V C H VERLAG GMBH EMBRYONIC STEM-CELLS FOCAL ADHESION KINASE NERVE GROWTH-FACTOR NEURITE OUTGROWTH EXTRACELLULAR-MATRIX HIPPOCAMPAL-NEURONS SILICON NANOWIRES CONTACT GUIDANCE IN-VITRO TOPOGRAPHY Neuron-Material Nanointerfaces: Surface Nanotopography Governs Neuronal Differentiation and Development Article 10.1002/cnma.201700063 1 CHEMNANOMAT, v.3, no.5, pp.278 - 287 CHEMNANOMAT 3 5 278 287 scie scopus 000403299200001 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Review EMBRYONIC STEM-CELLS FOCAL ADHESION KINASE NERVE GROWTH-FACTOR NEURITE OUTGROWTH EXTRACELLULAR-MATRIX HIPPOCAMPAL-NEURONS SILICON NANOWIRES CONTACT GUIDANCE IN-VITRO TOPOGRAPHY cell adhesion nanostructures neurite development neurochemistry stem cell differentiation