Yang, Yong Ryoul Song, Seungju Hwang, Hongik Jung, Hoon Jung Kim, Su-Jeong Yoon, Sora Hur, Jin-Hoe Park, Jae-Il Lee, Cheol Nam, Dougu Seo, Young-Kyo Kim, Joung-Hun Rhim, Hyewhon Suh, Pann-Ghill 2024-01-20T01:34:29Z 2024-01-20T01:34:29Z 2021-09-01 2017-04-03 2045-2322 https://pubs.kist.re.kr/handle/201004/122861 O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga(+/-)mice which have an increased level of O-GlcNAcylation, and found that Oga(+/-)mice exhibited impaired spatial learning and memory. Consistent with this result, Oga(+/-)mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-OGlcNAcylation in learning and memory. English NATURE PUBLISHING GROUP LINKED N-ACETYLGLUCOSAMINE RECEPTOR GLUR1 SUBUNIT GLCNAC MODIFICATION MASS-SPECTROMETRY AMPA RECEPTOR PHOSPHORYLATION SITES OXIDATIVE STRESS AGING BRAIN SYNAPSIN I PROTEIN Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation Article 10.1038/srep44921 1 SCIENTIFIC REPORTS, v.7 SCIENTIFIC REPORTS 7 scie scopus 000398105100001 2-s2.0-85016960086 Multidisciplinary Sciences Science & Technology - Other Topics Article LINKED N-ACETYLGLUCOSAMINE RECEPTOR GLUR1 SUBUNIT GLCNAC MODIFICATION MASS-SPECTROMETRY AMPA RECEPTOR PHOSPHORYLATION SITES OXIDATIVE STRESS AGING BRAIN SYNAPSIN I PROTEIN Long-term potentiation Spatial memory O-GlcNAcylation