Seo, Yujin Kim, Mi Kyoung Choo, Hyunah Chong, Youhoon 2024-01-20T01:34:43Z 2024-01-20T01:34:43Z 2021-09-04 2017-04 0039-7911 https://pubs.kist.re.kr/handle/201004/122875 Therapeutic potential of the D-ring methyl ethers of (-)-epigallocatechin-3- gallate [(-)- EGCG] warrants extensive structure-activity relationship study of various D-ring ethers of (-)-EGCG but, for this purpose, efficient synthetic strategy needs to be developed. In this study, efficient preparation of the 4 ''-O-alkyl-(-)-EGCGs (4a-e) was demonstrated using KI/K2CO3-promoted deacetylative alkylation of peracetyl (-)-EGCG, which could be broadly utilized for the preparation of various D-ring alkyl ethers of (-)-EGCG and thereby extensive structure-activity relationship study. English TAYLOR & FRANCIS INC TEA CATECHINS GREEN TEA EPIGALLOCATECHIN GALLATE POLYPHENOLS CELLS Facile synthesis of 4 ''-O-alkyl-(-)- EGCG derivatives through regioselective deacetylative alkylation Article 10.1080/00397911.2016.1278233 1 SYNTHETIC COMMUNICATIONS, v.47, no.7, pp.655 - 659 SYNTHETIC COMMUNICATIONS 47 7 655 659 scie scopus 000396796500003 2-s2.0-85013042422 Chemistry, Organic Chemistry Article TEA CATECHINS GREEN TEA EPIGALLOCATECHIN GALLATE POLYPHENOLS CELLS (-)-EGCG deacetylative alkylation regioselectivity