Huh, Myung Sook Lee, Eun Jung Koo, Heebeom Yhee, Ji Young Oh, Keun Sang Son, Sohee Lee, Sojin Kim, Sun Hwa Kwon, Ick Chan Kim, Kwangmeyung 2024-01-20T02:00:27Z 2024-01-20T02:00:27Z 2021-09-01 2017-04 2365-0869 https://pubs.kist.re.kr/handle/201004/122892 Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery. English SPRINGER INTERNATIONAL PUBLISHING AG GLYCOL CHITOSAN NANOPARTICLES SMALL INTERFERING RNA CONTROLLED DRUG-DELIVERY ENDOTHELIAL GROWTH-FACTOR MYELOID CELL LEUKEMIA-1 TUMOR-BEARING MICE IN-VIVO DELIVERY SIRNA DELIVERY TARGETED DELIVERY SYSTEMIC DELIVERY Polysaccharide-based Nanoparticles for Gene Delivery Article 10.1007/s41061-017-0114-y 1 TOPICS IN CURRENT CHEMISTRY, v.375, no.2 TOPICS IN CURRENT CHEMISTRY 375 2 scie scopus 000401323200012 2-s2.0-85014625960 Chemistry, Multidisciplinary Chemistry Review GLYCOL CHITOSAN NANOPARTICLES SMALL INTERFERING RNA CONTROLLED DRUG-DELIVERY ENDOTHELIAL GROWTH-FACTOR MYELOID CELL LEUKEMIA-1 TUMOR-BEARING MICE IN-VIVO DELIVERY SIRNA DELIVERY TARGETED DELIVERY SYSTEMIC DELIVERY Nanoparticle Polysaccharide Gene delivery siRNA delivery Nanotechnology Nanomedicine