Jeong, Hyosook Lee, Soo Hyeon Hwang, Yeonju Yoo, Hyundong Jung, Heesun Kim, Sun Hwa Mok, Hyejung 2024-01-20T02:00:30Z 2024-01-20T02:00:30Z 2021-09-01 2017-04 1616-5187 https://pubs.kist.re.kr/handle/201004/122895 Multivalent aptamer-siRNA conjugates containing multiple mucin-1 aptamers and BCL2specific siRNA are synthesized, and doxorubicin, an anthracycline anticancer drug, is loaded into these conjugates through intercalation with nucleic acids. These doxorubicin-incorporated multivalent aptamer-siRNA conjugates are transfected to mucin-1 overexpressing MCF-7 breast cancer cells and their multidrug-resistant cell lines. Doxorubicin-incorporated multivalent aptamer-siRNA conjugates exert promising anticancer effects, such as activation of caspase-3/7 and decrease of cell viability, on multidrug-resistant cancer cells because of their high intracellular uptake efficiency. Thus, this delivery system is an efficient tool for combination oncotherapy with chemotherapeutics and nucleic acid drugs to overcome multidrug resistance. English WILEY-V C H VERLAG GMBH MESOPOROUS SILICA NANOPARTICLES P-GLYCOPROTEIN SIRNA CO-DELIVERY DRUG-RESISTANCE CANCER DNA AGENTS ACID CYTOTOXICITY CHEMOTHERAPY Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells Article 10.1002/mabi.201600343 1 MACROMOLECULAR BIOSCIENCE, v.17, no.4 MACROMOLECULAR BIOSCIENCE 17 4 scie scopus 000398891200001 2-s2.0-85000983820 Biochemistry & Molecular Biology Materials Science, Biomaterials Polymer Science Biochemistry & Molecular Biology Materials Science Polymer Science Article MESOPOROUS SILICA NANOPARTICLES P-GLYCOPROTEIN SIRNA CO-DELIVERY DRUG-RESISTANCE CANCER DNA AGENTS ACID CYTOTOXICITY CHEMOTHERAPY combination therapy doxorubicin multidrug-resistant ancer cells multivalent aptamers siRNA