Lee, Soohyun Hwang, Eunjin Lee, Dongmyeong Choi, Jee Hyun 2024-01-20T02:00:42Z 2024-01-20T02:00:42Z 2021-09-01 2017-04 1226-2560 https://pubs.kist.re.kr/handle/201004/122907 Human studies of brain stimulation have demonstrated modulatory effects on the perception of pain. However, whether the primary somatosensory cortical activity is associated with antinociceptive responses remains unknown. Therefore, we examined the antinociceptive effects of neuronal activity evoked by optogenetic stimulation of primary somatosensory cortex. Optogenetic transgenic mice were subjected to continuous or pulse-train optogenetic stimulation of the primary somatosensory cortex at frequencies of 15, 30, and 40 Hz, during a tail clip test. Reaction time was measured using a digital high-speed video camera. Pulse-train optogenetic stimulation of primary somatosensory cortex showed a delayed pain response with respect to a tail clip, whereas no significant change in reaction time was observed with continuous stimulation. In response to the pulse-train stimulation, video monitoring and local field potential recording revealed associated paw movement and sensorimotor rhythms, respectively. Our results show that optogenetic stimulation of primary somatosensory cortex at beta and gamma frequencies blocks transmission of pain signals in tail clip test. English KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE ZONA INCERTA MAGNETIC STIMULATION BETA OSCILLATIONS SQUIRREL-MONKEY THALAMUS MOTOR MECHANISMS THERAPY NEURONS INJURY Pulse-train Stimulation of Primary Somatosensory Cortex Blocks Pain Perception in Tail Clip Test Article 10.5607/en.2017.26.2.90 1 EXPERIMENTAL NEUROBIOLOGY, v.26, no.2, pp.90 - 96 EXPERIMENTAL NEUROBIOLOGY 26 2 90 96 scie scopus kci ART002221551 000406862500003 2-s2.0-85018693396 Medicine, Research & Experimental Neurosciences Research & Experimental Medicine Neurosciences & Neurology Article ZONA INCERTA MAGNETIC STIMULATION BETA OSCILLATIONS SQUIRREL-MONKEY THALAMUS MOTOR MECHANISMS THERAPY NEURONS INJURY optogenetic stimulation tail clip test sensorimotor rhythms primary somatosensory cortex pain perception