Bruns, Oliver T. Bischof, Thomas S. Harris, Daniel K. Franke, Daniel Shi, Yanxiang Riedemann, Lars Bartelt, Alexander Jaworski, Frank B. Carr, Jessica A. Rowlands, Christopher J. Wilson, Mark W. B. Chen, Ou Wei, He Hwang, Gyu Weon Montana, Daniel M. Coropceanu, Igor Achorn, Odin B. Kloepper, Jonas Heeren, Joerg So, Peter T. C. Fukumura, Dai Jensen, Klavs F. Jain, Rakesh K. Bawendi, Moungi G. 2024-01-20T02:00:53Z 2024-01-20T02:00:53Z 2021-09-01 2017-04 https://pubs.kist.re.kr/handle/201004/122918 For in vivo imaging, the short-wavelength infrared region (SWIR; 1,000-2,000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolour imaging and fast acquisition speed afforded by the SWIR quantum dots, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature. English NATURE PUBLISHING GROUP Next-generation in vivo optical imaging with short-wave infrared quantum dots Article 10.1038/s41551-017-0056 1 Nature Biomedical Engineering, v.1, no.4 Nature Biomedical Engineering 1 4 N scie scopus 000418855100007 2-s2.0-85027417266 Engineering, Biomedical Engineering Article LIPOPROTEIN METABOLISM CARBON NANOTUBES NANOCRYSTALS EMISSION BRIGHT VELOCITY DENSITY WINDOW BRAIN PROBE quantum dots SWIR in vivo