Heo, Dong Nyoung Kim, Han-Jun Lee, Yi Jae Heo, Min Lee, Sang Jin Lee, Donghyun Do, Sun Hee Lee, Soo Hyun Kwon, Il Keun 2024-01-20T02:02:00Z 2024-01-20T02:02:00Z 2022-01-10 2017-03 1936-0851 https://pubs.kist.re.kr/handle/201004/122974 Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device appliCations for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch, and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing. We demonstrate an NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility. Furthermore, the electrode can record stable neural signals for extended periods of time, resulting in decreased mechanical mismatch, neural compression, and contact area. NF-based electrodes with highly flexible and body-fluid-permeable properties could enable future neural interfacing applications. English AMER CHEMICAL SOC CONDUCTING-POLYMER NANOTUBES PERIPHERAL NERVOUS-SYSTEM RAT SCIATIC-NERVE CUFF ELECTRODE MECHANICAL-PROPERTIES MULTIELECTRODE ARRAY SPINAL-CORD IN-VIVO STIMULATION SUPERCAPACITORS Flexible and Highly Biocompatible Nanofiber-Based Electrodes for Neural Surface Interfacing Article 10.1021/acsnano.6b08390 1 ACS NANO, v.11, no.3, pp.2961 - 2971 ACS NANO 11 3 2961 2971 scie scopus 000398014900062 2-s2.0-85016416249 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article CONDUCTING-POLYMER NANOTUBES PERIPHERAL NERVOUS-SYSTEM RAT SCIATIC-NERVE CUFF ELECTRODE MECHANICAL-PROPERTIES MULTIELECTRODE ARRAY SPINAL-CORD IN-VIVO STIMULATION SUPERCAPACITORS nerve electrode flexible device neural interfacing electrospun nanofiber inkjet printing