Jo, Byeong Cheol Yoon, Hyun Jung Ok, Myoung-Ryul Wu, Sangwook 2024-01-20T02:02:59Z 2024-01-20T02:02:59Z 2021-09-01 2017-03 1559-4106 https://pubs.kist.re.kr/handle/201004/123030 Graphene is a nanomaterial that is widely used in electronics, biomedicine, and drug-delivery systems. Although it has many industrial applications, the cytotoxicity of graphene has not been sufficiently studied. In this study, the authors used molecular dynamics simulation to investigate how a graphene nanosheet affects a blood-coagulation protein, namely, a tissue factor/FVIIa binary complex bound to a lipid bilayer membrane, in a 4: 1 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2oleoyl-sn-glycero-3-phospho-l-serine lipid bilayer mixture. Based on the results, the authors suggest a mechanism for the cytotoxicity of graphene nanosheets to blood-coagulation protein at the molecular level. (C) 2017 American Vacuum Society. English AMER INST PHYSICS WALL CARBON NANOTUBES PULMONARY TOXICITY FACTOR VIIA STRENGTH PHASE FIELD LUNG Molecular dynamics simulation of cytotoxicity of graphene nanosheets to blood-coagulation protein Article 10.1116/1.4977076 1 BIOINTERPHASES, v.12, no.1 BIOINTERPHASES 12 1 scie scopus 000398525300003 2-s2.0-85014644771 Biophysics Materials Science, Biomaterials Biophysics Materials Science Article; Proceedings Paper WALL CARBON NANOTUBES PULMONARY TOXICITY FACTOR VIIA STRENGTH PHASE FIELD LUNG molecular dynamics biophysics blood protein graphene