Joe, I-Seul Kim, Jong-Hwan Kim, Hanna Hong, Jung-Hwa Kim, Mirang Park, Mikyoung 2024-01-20T02:03:16Z 2024-01-20T02:03:16Z 2021-09-01 2017-02-27 1932-6203 https://pubs.kist.re.kr/handle/201004/123044 Cyclin Y (CCNY), which is a cyclin protein known to play a role in cell division, is unexpectedly and thus interestingly expressed in non-proliferating neuronal cells. There have been only a few studies reporting the neuronal functions of CCNY in synapse remodeling and hippocampal long-term potentiation. Therefore, we here provide global and comprehensive information on the putative functions of CCNY in biological and functional pathways in neuronal systems. We adopted high-throughput RNA-sequencing technology for analyzing transcriptomes regulated by CCNY and utilized bioinformatics for identifying putative molecules, biological processes, and functional pathways that are possibly connected to CCNY functions in hippocampal neuronal cells of rats. We revealed that several enriched annotation terms and pathways associated with CCNY expression within neurons, including apoptosis, learning or memory, synaptic plasticity, actin cytoskeleton, focal adhesion, extracellular matrix-receptor interaction and chemokine signaling pathway are targeted by CCNY. In addition, the mRNA levels of some genes enriched for those annotation terms and pathways or genes reported to be altered in Alzheimer's disease mouse model were further validated by quantitative real-time PCR in hippocampal neuronal cells. The present study provides an excellent resource for future investigations of CCNY functions in neuronal systems. English PUBLIC LIBRARY SCIENCE LONG-TERM POTENTIATION LARGE GENE LISTS ACTIN DYNAMICS SYNAPTIC-TRANSMISSION ALZHEIMERS-DISEASE PROTEIN-SYNTHESIS DENDRITIC SPINES CELL-CYCLE MYOSIN VB PLASTICITY Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons Article 10.1371/journal.pone.0172547 1 PLOS ONE, v.12, no.2 PLOS ONE 12 2 scie scopus 000395934400026 2-s2.0-85014027478 Multidisciplinary Sciences Science & Technology - Other Topics Article LONG-TERM POTENTIATION LARGE GENE LISTS ACTIN DYNAMICS SYNAPTIC-TRANSMISSION ALZHEIMERS-DISEASE PROTEIN-SYNTHESIS DENDRITIC SPINES CELL-CYCLE MYOSIN VB PLASTICITY Cyclin Y Transcriptome hippocampus neurons