Atabaev, Timur Sh Lee, Jong Ho Shin, Yong Cheol Han, Dong-Wook Choo, Ki Seok Jeon, Ung Bae Hwang, Jae Yeon Yeom, Jeong A. Kim, Hyung-Kook Hwang, Yoon-Hwae 2024-01-20T02:04:12Z 2024-01-20T02:04:12Z 2022-01-25 2017-02 2079-4991 https://pubs.kist.re.kr/handle/201004/123095 Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T-1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging. English MDPI Eu, Gd-Codoped Yttria Nanoprobes for Optical and T-1-Weighted Magnetic Resonance Imaging Article 10.3390/nano7020035 1 Nanomaterials, v.7, no.2 Nanomaterials 7 2 Y scie scopus 000400761600013 2-s2.0-85012982023 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Chemistry Science & Technology - Other Topics Materials Science Physics Article BIOMEDICAL APPLICATIONS PARTICLES NANOPARTICLES FABRICATION CYTOTOXICITY yttria nanoprobes optical imaging magnetic resonance imaging cytotoxicity T-1-weighted contrast agent