Kim, Bowon Kocsis, Bernat Hwang, Eunjin Kim, Youngsoo Strecker, Robert E. McCarley, Robert W. Choi, Jee Hyun 2024-01-20T02:30:31Z 2024-01-20T02:30:31Z 2021-09-01 2017-02 0027-8424 https://pubs.kist.re.kr/handle/201004/123147 Homeostatic rebound in rapid eye movement (REM) sleep normally occurs after acute sleep deprivation, but REM sleep rebound settles on a persistently elevated level despite continued accumulation of REM sleep debt during chronic sleep restriction (CSR). Using highdensity EEG in mice, we studied how this pattern of global regulation is implemented in cortical regions with different functions and network architectures. We found that across all areas, slow oscillations repeated the behavioral pattern of persistent enhancement during CSR, whereas high-frequency oscillations showed progressive increases. This pattern followed a common rule despite marked topographic differences. The findings suggest that REM sleep slow oscillations may translate top-down homeostatic control to widely separated brain regions whereas fast oscillations synchronizing local neuronal ensembles escape this global command. These patterns of EEG oscillation changes are interpreted to reconcile two prevailing theories of the function of sleep, synaptic homeostasis and sleep dependent memory consolidation. English National Academy of Sciences Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation Article 10.1073/pnas.1615230114 1 Proceedings of the National Academy of Sciences of the United States of America, v.114, no.9, pp.E1727 - E1736 Proceedings of the National Academy of Sciences of the United States of America 114 9 E1727 E1736 N scie scopus 000395101200019 2-s2.0-85014122568 Multidisciplinary Sciences Science & Technology - Other Topics Article PONTINE-WAVE GENERATOR EYE-MOVEMENT SLEEP GAMMA-OSCILLATIONS CORTICAL NETWORK VIGILANCE STATE GENE-EXPRESSION HZ OSCILLATION SPATIAL MEMORY BRAIN RHYTHMS THETA RHYTHM chronic sleep deprivation low-frequency cortical oscillation fast corticaloscillation EEG topography sleep function