Chang, Hyeyoun Yhee, Ji Young Jang, Gun Hyuk You, Dong Gil Ryu, Ju Hee Choi, Yongwhan Na, Jin Hee Park, Jae Hyung Lee, Kwan Hyi Choi, Kuiwon Kim, Kwangmeyung Kwon, Ick Chan 2024-01-20T02:33:19Z 2024-01-20T02:33:19Z 2021-09-04 2016-12-28 0168-3659 https://pubs.kist.re.kr/handle/201004/123298 Nanoparticles have resulted in great progress in biomedical imaging and targeted drug delivery in cancer theranostics. To develop nanoparticles as an effective carrier system for therapeutics, chemical structures and physicochemical properties of nanoparticle may provide a reliable means to predict the in vitro characteristics of nanoparticles. However, in vivo fates of nanoparticles, such as pharmacokinetics and tumor targeting efficiency of nanoparticles, have been difficult to predict beforehand. To predict the in vivo fates of nanoparticles in tumor-bearing mice, differences in physicochemical properties and in vitro cancer cell/macrophage uptake of 5 different nanoparticles with mean diameter of 200-250 nm were comparatively analyzed, along with their circulation in adult zebrafish. The nanoparticles which showed favorable cellular uptake by macrophages indicated high unintended liver accumulation in vivo, which is attributed to the clearance by the reticuloendothelial system (RES). In addition, blood circulation of nanoparticles was closely correlated in adult zebrafish and in mice that the zebrafish experiment may elucidate the in vivo behavior of nanoparticles in advance of the in vivo experiment using mammal animal models. This comparative study on various nanoparticles was conducted to provide the basic information on predicting the in vivo fates of nanoparticles prior to the in vivo experiments. (C) 2016 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV DRUG-DELIVERY SYSTEM Predicting the in vivo accumulation of nanoparticles in tumor based on in vitro macrophage uptake and circulation in zebrafish Article 10.1016/j.jconrel.2016.07.025 1 JOURNAL OF CONTROLLED RELEASE, v.244, pp.205 - 213 JOURNAL OF CONTROLLED RELEASE 244 205 213 scie scopus 000393128200008 2-s2.0-85006121034 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article; Proceedings Paper DRUG-DELIVERY SYSTEM Macrophage Nanoparticle Reticuloendothelial system Targeting Tumor