Koo, Song Yi Mok, Il-Kyoon Pan, Cheol-Ho Kim, Sang Min 2024-01-20T02:33:42Z 2024-01-20T02:33:42Z 2021-08-31 2016-12-14 0021-8561 https://pubs.kist.re.kr/handle/201004/123319 To facilitate the utilization of fucoxanthin (FX), a valuable marine carotenoid, in the food industry, FX-loaded casein nanoparticles (FX-CN) and chitosan-coated FX-CN (FX-CS-CN) were developed using the FX-enriched fraction from Phaeodactylum tricornutum. Two nanoscale particles (237 +/- 13 nm for FX-CN and 277 +/- 26 nm for FX-CN-CN) with spherical and smooth surfaces showed over 71% encapsulation efficiency and polydispersity index (PDI) value of 0.31-0.39 in water. Owing to the chitosan coating, FX-CS-CN showed a positive zeta potential (24.00 mV), whereas that of FX-CN was negative (-12.87 mV). In vitro simulated digestion demonstrated better FX bioaccessibility from the nanoparticles versus P. tricornutum powder (Pt-powder) and from FX-CN versus FX-CS-CN. However, in C57BL/6 mice, fucoxanthinol absorption to the blood circulation was two times higher for FX-CS-CN versus FX-CN, possibly due to increased retention or adsorption to mucin by the cationic biopolymer in the chitosan-coated particles. These results demonstrate that FX-CS-CN can enable the application of FX, with improved bioavailability and water dispersibility, in the food industry. English AMER CHEMICAL SOC IN-VIVO PHARMACOKINETICS SODIUM CASEINATE DRUG-DELIVERY STABILITY VITRO CURCUMIN FORMULATION NANOGELS SYSTEMS CARRIER Preparation of Fucoxanthin-Loaded Nanoparticles Composed of Casein and Chitosan with Improved Fucoxanthin Bioavailability Article 10.1021/acs.jafc.6b04376 1 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.49, pp.9428 - 9435 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64 49 9428 9435 scie scopus 000389962900020 2-s2.0-85006255971 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article IN-VIVO PHARMACOKINETICS SODIUM CASEINATE DRUG-DELIVERY STABILITY VITRO CURCUMIN FORMULATION NANOGELS SYSTEMS CARRIER bioavailability casein chitosan fucoxanthin nanoparticles Phaeodactylum tricornutum