Kim, Kyoung-Ran Kim, Hyo Young Lee, Yong-Deok Ha, Jong Seong Kang, Ji Hee Jeong, Hansaem Bang, Duhee Ko, Young Tag Kim, Sehoon Lee, Hyukjin Ahn, Dae-Ro 2024-01-20T02:33:45Z 2024-01-20T02:33:45Z 2021-09-05 2016-12-10 0168-3659 https://pubs.kist.re.kr/handle/201004/123321 Nanoparticle delivery systems have been extensively investigated for targeted delivery of anticancer drugs over the past decades. However, it is still a great challenge to overcome the drawbacks of conventional nanoparticle systems such as liposomes and micelles. Various novel nanomaterials consist of natural polymers are proposed to enhance the therapeutic efficacy of anticancer drugs. Among them, deoxyribonucleic acid (DNA) has received much attention as an emerging material for preparation of self-assembled nanostructures with precise control of size and shape for tailored uses. In this study, self-assembled mirror DNA tetrahedron nanostructures is developed for tumor-specific delivery of anticancer drugs. L-DNA, a mirror form of natural D-DNA, is utilized for resolving a poor serum stability of natural D-DNA. The mirror DNA nanostructures show identical thermodynamic properties to that of natural D-DNA, while possessing far enhanced serum stability. This unique characteristic results in a significant effect on the pharmacokinetics and biodistribution of DNA nanostructures. It is demonstrated that the mirror DNA nanostructures can deliver anticancer drugs selectively to tumors with enhanced cellular and tissue penetration. Furthermore, the mirror DNA nanostructures show greater anticancer effects as compared to that of conventional PEGylated liposomes. Our new approach provides an alternative strategy for tumor-specific delivery of anticancer drugs and highlights the promising potential of the mirror DNA nanostructures as a novel drug delivery platform. (C) 2016 Elsevier B.V. All rights reserved. English ELSEVIER PEGYLATED LIPOSOMAL DOXORUBICIN RNA NANOPARTICLES CANCER DESIGN NANOCARRIERS PHARMACOKINETICS NANOTECHNOLOGY TETRAHEDRON EFFICACY DOXIL(R) Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs Article 10.1016/j.jconrel.2016.10.015 1 JOURNAL OF CONTROLLED RELEASE, v.243, pp.121 - 131 JOURNAL OF CONTROLLED RELEASE 243 121 131 scie scopus 000392290000011 2-s2.0-84992036172 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article PEGYLATED LIPOSOMAL DOXORUBICIN RNA NANOPARTICLES CANCER DESIGN NANOCARRIERS PHARMACOKINETICS NANOTECHNOLOGY TETRAHEDRON EFFICACY DOXIL(R) DNA nanostructure Mirror DNA Tumor-targeted delivery Doxorubicin