Kim, Mi Kyoung Park, Kwang-su Jung, Woong Choo, Hyunah Chong, Youhoon 2024-01-20T02:34:16Z 2024-01-20T02:34:16Z 2021-09-05 2016-12 0253-2964 https://pubs.kist.re.kr/handle/201004/123351 In this study, quercetin and its conjugates with pivaloxymethyl, glutamic acid, or alanine promoieties were evaluated for their ability to sensitize wild type P. aeruginosa to -lactam antibiotics. Among the quercetin conjugates, quercetin 7-O-glutamate was as potent as phenylalanine-arginine -naphthylamide (PAN), and addition of this conjugate (25 mu g/mL) resulted in significant reduction of minimum inhibitory concentrations (MICs) of the -lactam antibiotics such as piperacillin, cefotaxime, and ceftazidime (two-, four-, and eight-fold, respectively). Quercetin 7-O-glutamate was also effective in sensitizing P. aeruginosa to bulky antibiotics such as vancomycin and erythromycin through permeabilization of the outer membrane of the Gram-negative bacterium. The outer membrane-destabilizing activity of 7-O-glutamate was similar to that of PAN, and it decreased the MICs of both vancomycin and erythromycin by 16-fold. English WILEY-V C H VERLAG GMBH MULTIDRUG-RESISTANCE EFFLUX STABILITY PERMEABILITY INHIBITORS Quercetin 7-O-Glutamate Sensitizes P-aeruginosa to -Lactams and Vancomycin Article 10.1002/bkcs.11023 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.12, pp.2025 - 2028 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 37 12 2025 2028 scie scopus kci ART002172608 000390270200022 2-s2.0-85003520603 Chemistry, Multidisciplinary Chemistry Article MULTIDRUG-RESISTANCE EFFLUX STABILITY PERMEABILITY INHIBITORS Quercetin conjugate Sensitization P. aeruginosa beta-lactam Vancomycin