Kim, Juhyeon Cho, Yong Seo Min, Sun-Joon 2024-01-20T02:34:40Z 2024-01-20T02:34:40Z 2021-09-05 2016-12 0253-2964 https://pubs.kist.re.kr/handle/201004/123373 A transition-metal-free and regioselective synthesis of a series of 2-amino-4-alkoxypyrimidines is described. The SNAr alkoxylation of 2,4-dichloropyrimidines regioselectively provided 2-chloro-4-alkoxypyrimidines, which were subsequently subject to the second SNAr amination with cyclic amines in the presence of triethylamine at high temperature to afford 2-amino-4-alkoxypyrimidines in good overall yield. English WILEY-V C H VERLAG GMBH CROSS-COUPLING REACTIONS REGIOSELECTIVE 4-AMINO-DE-CHLORINATION HETEROCYCLES PYRIMIDINES INHIBITOR EFFICIENT Facile Synthesis of 2-Amino-4-alkoxypyrimidines via Consecutive Nucleophilic Aromatic Substitution (SNAr) Reactions Article 10.1002/bkcs.11014 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.12, pp.1998 - 2008 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 37 12 1998 2008 scie scopus kci ART002172604 000390270200018 2-s2.0-85003703938 Chemistry, Multidisciplinary Chemistry Article CROSS-COUPLING REACTIONS REGIOSELECTIVE 4-AMINO-DE-CHLORINATION HETEROCYCLES PYRIMIDINES INHIBITOR EFFICIENT 2-Amino-4-alkoxypyrimidines Nucleophilic aromatic substitution Regioselectivity Alkoxylation Amination