Han, Myung Woul Lee, Jong Cheol Park, Seung-Yoon Kim, Young Min Cho, Kyung-Ja Kim, Seong Who Lee, Myungjin Nam, Soon Yuhl Kim, In-San Kim, Sang Yoon 2024-01-20T03:00:25Z 2024-01-20T03:00:25Z 2021-09-04 2016-12 0250-7005 https://pubs.kist.re.kr/handle/201004/123385 Background/Aim: Lymph node (LN) metastasis of solid types of tumors has important clinical significance and it is therefore critical to identify molecular biomarkers that would enable the selection of patients with LN metastases. Patients and Methods: We evaluated the expression of stabilin-2 in primary oral tongue tumors and metastatic LNs using immunohistochemical staining. The correlation between risk factors and nodal metastasis was assessed and disease-free survival was analyzed. Results: Stabilin-2 expression remained a significant predictor of LN metastasis and the factor affecting recurrence in tongue cancer. Most importantly, all metastatic tumors of tongue, lung, stomach and colon cancers stained positive for stabilin-2 and stabilin-2 was expressed strongly in the sinusoidal endothelial cell of metastatic LNs. Conclusion: Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors. English INT INST ANTICANCER RESEARCH CC-CHEMOKINE RECEPTOR-7 CELL CORPSE CLEARANCE HYALURONAN RECEPTOR PHOSPHATIDYLSERINE ENGULFMENT EXPRESSION INTEGRIN MACROPHAGES CARCINOMA DOMAINS Homotypic Interaction of Stabilin-2 Plays a Critical Role in Lymph Node Metastasis of Tongue Cancer Article 10.21873/anticanres.11267 1 ANTICANCER RESEARCH, v.36, no.12, pp.6611 - 6618 ANTICANCER RESEARCH 36 12 6611 6618 scie scopus 000390946700053 2-s2.0-85002193700 Oncology Oncology Article CC-CHEMOKINE RECEPTOR-7 CELL CORPSE CLEARANCE HYALURONAN RECEPTOR PHOSPHATIDYLSERINE ENGULFMENT EXPRESSION INTEGRIN MACROPHAGES CARCINOMA DOMAINS Stabilin-2 lymph node metastasis tongue cancer tumor biomarker lymphatic endothelial cells