Lee, Eun Jung Lee, Na Kyeong Kim, In-San 2024-01-20T03:01:20Z 2024-01-20T03:01:20Z 2021-09-04 2016-11-15 0169-409X https://pubs.kist.re.kr/handle/201004/123432 Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented. (C) 2016 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV VIRUS-LIKE PARTICLES COWPEA MOSAIC-VIRUS SUPRAMOLECULAR BUILDING-BLOCKS DENDRITIC CELL ACTIVATION HORSE SPLEEN APOFERRITIN HEAT-SHOCK-PROTEIN VIRAL NANOPARTICLES CAGE NANOPARTICLES TARGETED DELIVERY IN-VITRO Bioengineered protein-based nanocage for drug delivery Article 10.1016/j.addr.2016.03.002 1 ADVANCED DRUG DELIVERY REVIEWS, v.106, pp.157 - 171 ADVANCED DRUG DELIVERY REVIEWS 106 157 171 scie scopus 000387525500012 2-s2.0-84962128027 Pharmacology & Pharmacy Pharmacology & Pharmacy Review VIRUS-LIKE PARTICLES COWPEA MOSAIC-VIRUS SUPRAMOLECULAR BUILDING-BLOCKS DENDRITIC CELL ACTIVATION HORSE SPLEEN APOFERRITIN HEAT-SHOCK-PROTEIN VIRAL NANOPARTICLES CAGE NANOPARTICLES TARGETED DELIVERY IN-VITRO Protein-based nanocage Bioengineering Functionalization Drug delivery Cancer therapy