Han, Sungmin Kim, Donghwee Kim, Hyungmin Park, Jong Woong Youn, Inchan 2024-01-20T03:01:40Z 2024-01-20T03:01:40Z 2021-09-04 2016-11-09 0959-4965 https://pubs.kist.re.kr/handle/201004/123449 The current study aimed to investigate whether electrical stimulation could prevent apoptotic neuronal cell death during treatment with cytosine arabinoside (ara-C). From in-vitro experiments, the effects of electrical stimulation were assessed on neurite fragmentation and neuronal cell death in ara-C-treated dorsal root ganglion (DRG) explants. Ara-C treatment increased neurite fragmentation and neuronal cell death in DRG explants and activated caspase-3 by cleaving it, which could induce apoptosis. Electrical stimulation can significantly reduce neurite fragmentation and neuronal cell death compared with nonelectrically stimulated groups. Furthermore, electrical stimulation inhibited caspase-3 activation and reduced apoptotic neuronal death in DRG explants. It was suggested that the neuroprotective effect of electrical stimulation is likely mediated by the inhibition of caspase-3 activation and therefore the inhibition of apoptosis following ara-C treatment. English LIPPINCOTT WILLIAMS & WILKINS CENTRAL-NERVOUS-SYSTEM MULTIELECTRODE ARRAYS SYMPATHETIC NEURONS IN-VITRO CHEMOTHERAPY EXPRESSION LEUKEMIA GROWTH BDNF NGF Electrical stimulation inhibits cytosine arabinoside-induced neuronal death by preventing apoptosis in dorsal root ganglion neurons Article 10.1097/WNR.0000000000000681 1 NEUROREPORT, v.27, no.16, pp.1217 - 1224 NEUROREPORT 27 16 1217 1224 scie scopus 000385962400006 2-s2.0-84986203456 Neurosciences Neurosciences & Neurology Article CENTRAL-NERVOUS-SYSTEM MULTIELECTRODE ARRAYS SYMPATHETIC NEURONS IN-VITRO CHEMOTHERAPY EXPRESSION LEUKEMIA GROWTH BDNF NGF apoptotic neuronal death dorsal root ganglion neuron electrical stimulation neurotoxicity