Kim, Tae Hee Kim, Soo Hyun Jung, Youngmee 2024-01-20T03:02:56Z 2024-01-20T03:02:56Z 2021-09-04 2016-11 1743-5889 https://pubs.kist.re.kr/handle/201004/123520 Insufficient angiogenesis in severe wounds delays wound repair because of a lack of blood supply to the wound site. Therefore, pro-angiogenic therapeutics may enhance wound repair. Many studies have investigated various physical and biochemical cues to improve angiogenesis, such as biocompatible materials, surface modifications, angiogenic factors and coculture systems using various cell types. However, the present capability to mimic the micro-and nanostructure of the natural microenvironment, particularly its porous, fibrous features, is limited. Nanotopography may represent a promising tool to overcome these limitations. Here, we discuss various approaches to the use of nanotopography to enhance angiogenesis and consider the combination of coculture systems with nanotopography to mimic the native environment for promotion of angiogenesis in wound healing and repair. English FUTURE MEDICINE LTD SMOOTH-MUSCLE-CELLS ACID MICRO-PATTERN ENDOTHELIAL-CELLS EXTRACELLULAR-MATRIX TUBE FORMATION LOW-DENSITY PERICYTES MECHANISMS NANOSCALE ADHESION The effects of nanotopography and coculture systems to promote angiogenesis for wound repair Article 10.2217/nnm-2016-0237 1 NANOMEDICINE, v.11, no.22, pp.2997 - 3007 NANOMEDICINE 11 22 2997 3007 scie scopus 000386899200009 2-s2.0-84994609059 Biotechnology & Applied Microbiology Nanoscience & Nanotechnology Biotechnology & Applied Microbiology Science & Technology - Other Topics Article SMOOTH-MUSCLE-CELLS ACID MICRO-PATTERN ENDOTHELIAL-CELLS EXTRACELLULAR-MATRIX TUBE FORMATION LOW-DENSITY PERICYTES MECHANISMS NANOSCALE ADHESION angiogenesis coculture system endothelial cells nanotopography pericyte