Ha, Min Woo Choi, Sujee Kim, Seek Lee, Jun Young Lee, Jae Kyun Lee, Jeeyeon Hong, Suckchang Park, Hyeung-geun 2024-01-20T03:03:06Z 2024-01-20T03:03:06Z 2021-09-03 2016-11 2046-2069 https://pubs.kist.re.kr/handle/201004/123529 The enantioselective synthesis of alpha-acyloxy-alpha-alkylmalonates was developed as an efficient method for producing chiral alpha-tertiary alcohols, which are potentially valuable intermediates in the synthesis of natural products and pharmaceuticals. The efficient enantioselective alpha-alkylation of diphenylmethyl tert-butyl alpha-acyloxymalonates was accomplished via phase-transfer catalysis in the presence of (S, S)-3,4,5-trifluorophenyl-NAS bromide to afford the corresponding alpha-acyloxy-alpha-alkylmalonates at high chemical (up to 99%) and optical (up to 93% ee) yields, which could be readily converted to versatile chiral intermediates with a chiral alpha-tertiary alcohol group. English ROYAL SOC CHEMISTRY PIG-LIVER ESTERASE BETA-KETO-ESTERS ASYMMETRIC-SYNTHESIS AMINO-ACIDS STEREOSELECTIVE-SYNTHESIS ORGANIC-SYNTHESIS ATOM-TRANSFER AMINOXYLATION (R)-BICALUTAMIDE KETOESTERS Phase-transfer catalyzed enantioselective alpha-alkylation of alpha-acyloxymalonates: construction of chiral alpha-hydroxy quaternary stereogenic centers Article 10.1039/c6ra15121c 1 RSC ADVANCES, v.6, no.81, pp.77427 - 77430 RSC ADVANCES 6 81 77427 77430 scie scopus 000382482200034 2-s2.0-85017440437 Chemistry, Multidisciplinary Chemistry Article PIG-LIVER ESTERASE BETA-KETO-ESTERS ASYMMETRIC-SYNTHESIS AMINO-ACIDS STEREOSELECTIVE-SYNTHESIS ORGANIC-SYNTHESIS ATOM-TRANSFER AMINOXYLATION (R)-BICALUTAMIDE KETOESTERS chiral a-hydroxy x-ray crystal enantioselective