Singh, Ajay Kim, Woong Kim, Youngsun Jeong, Keunsoo Kang, Chi Soo Kim, YoungSoo Koh, Joonseok Mahajan, Supriya D. Prasad, Paras N. Kim, Sehoon 2024-01-20T03:03:34Z 2024-01-20T03:03:34Z 2021-09-05 2016-10-18 1616-301X https://pubs.kist.re.kr/handle/201004/123552 Theranostic photonic nanoparticles (TPNs) that cross the blood-brain barrier (BBB) and efficiently deliver a therapeutic agent to treat brain diseases, simultaneously providing optical tracking of drug delivery and release, are introduced. These TPNs are constructed by physical encapsulation of visible and/or near-infrared photonic molecules, in an ultrasmall micellar structure (<15 nm). Phytochemical curcumin is employed as a therapeutic as well as visible-emitting photonic component. In vitro BBB model studies and animal imaging, as well as ex vivo examination, reveal that these TPNs are capable of transmigration across the BBB and subsequent accumulation near the orthotopic xenograft of glioblastoma multiforme (GBM) that is the most common and aggressive brain tumor whose vasculature retains permeability-resistant properties. The intracranial delivery and release of curcumin can be visualized by imaging fluorescence produced by energy transfer from curcumin as the donor to the near-infrared emitting dye, coloaded in TPN, where curcumin induced apoptosis of glioma cells. At an extremely low dose of TPN, a significant therapeutic outcome against GBM is demonstrated noninvasively by bioluminescence monitoring of time-lapse proliferation of luciferase-expressing U-87 MG human GBM in the brain. This approach of TPN can be generally applied to a broad range of brain diseases. English WILEY-V C H VERLAG GMBH BLOCK-COPOLYMERS CURCUMIN PERMEABILITY FLUORESCENCE DELIVERY Multifunctional Photonics Nanoparticles for Crossing the Blood-Brain Barrier and Effecting Optically Trackable Brain Theranostics Article 10.1002/adfm.201602808 1 ADVANCED FUNCTIONAL MATERIALS, v.26, no.39, pp.7057 - 7066 ADVANCED FUNCTIONAL MATERIALS 26 39 7057 7066 scie scopus 000387145300002 2-s2.0-84985904914 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article BLOCK-COPOLYMERS CURCUMIN PERMEABILITY FLUORESCENCE DELIVERY blood？brain barrier brain tumor therapy drug delivery fluorescence imaging theranostic nanoparticles