Lih, Eugene Chi, So Yoon II Son, Tae Joung, Yoon Ki Han, Dong Keun 2024-01-20T03:04:36Z 2024-01-20T03:04:36Z 2021-09-05 2016-10 2157-9083 https://pubs.kist.re.kr/handle/201004/123609 Nitinol (NiTi) has been used in a wide range of medical applications, specifically endovascular devices such as catheters, stents, and superelastic needles due to their unique mechanical properties and shape memory behavior. However, there have been still limitations because of the poor blood compatibility of NiTi which causes thrombogenicity and platelet activation and aggregation. In this study, the surface of NiTi substrates was modified by grafting dopamine-conjugated hyaluronic acid (HADA) to improve blood compatibility of NiTi. HADA conjugates were synthesized by carbodiimide coupling reaction and characterized using H-1-NMR, ATR-FTIR, and UV spectrometers. HADA conjugates with different concentrations (1, 4, and 8 mg/mL) were immobilized on NiTi surfaces at pH 8.5, indicating an oxidation of dopamine. The physico-mechanical properties of hyaluronic acid immobilized NiTi (NiTi/HADA) substrates were analyzed with FE-SEM, water contact angle, XPS, AFM, and micro BCA assay. The blood compatibility results showed that not only protein adsorption but also platelet adhesion on NiTi/HADA substrates were reduced, compared with bare NiTi control. Also, their proper cytocompatibility was confirmed using Live/Dead assay with human umbilical vein endothelial cells. The obtained results demonstrate that NiTi/HADA substrates would be promising for blood-contacting medical applications including stents, vena cava filters, and atrial septal defect closure devices. English AMER SCIENTIFIC PUBLISHERS SHAPE-MEMORY ALLOYS PROTEIN ADSORPTION IN-VITRO BIOCOMPATIBILITY BEHAVIOR STENT HEMOCOMPATIBILITY IMMOBILIZATION POLYMERIZATION CORROSION Facile Surface Modification of Nitinol with Dopamine-Conjugated Hyaluronic Acid for Improving Blood Compatibility Article 10.1166/jbt.2016.1507 1 JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, v.6, no.10, pp.780 - 787 JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 6 10 780 787 scie scopus 000385565900004 2-s2.0-84989257138 Cell & Tissue Engineering Cell Biology Article SHAPE-MEMORY ALLOYS PROTEIN ADSORPTION IN-VITRO BIOCOMPATIBILITY BEHAVIOR STENT HEMOCOMPATIBILITY IMMOBILIZATION POLYMERIZATION CORROSION Vascular Stent Nitinol Hyaluronic Acid Surface Modification Blood Compatibility